LymphedemaV1, Main, Exploration, bibRecord, 007F32

Novel Expression and Characterization of Lymphatic Vessel Endothelial Hyaluronate Receptor 1 (LYVE-1) by Conjunctival Cells

Identifieur interne : 007F32 ( Main/Exploration ); précédent : 007F31; suivant : 007F33

Novel Expression and Characterization of Lymphatic Vessel Endothelial Hyaluronate Receptor 1 (LYVE-1) by Conjunctival Cells

Auteurs : Lu Chen ; Claus Cursiefen ; Stefano Barabino ; Qiang Zhang ; M. Reza Dana

Source :

Investigative ophthalmology & visual science [ 0146-0404 ] ; 2005.

RBID : PMC:1397798

Abstract

Purpose. Lymphatic vessel endothelial hyaluronic acid receptor (LYVE-1) is a newly discovered lymphatic-specific marker. To date, there is no report of its expression on conjunctival cells. The purpose of this study was to investigate the expression of LYVE-1 in normal conjunctiva, to phenotype LYVE-1⁺ cells, and to study changes in their expression levels during corneal inflammation.

Methods. Flatmounted conjunctivae or cross sections of eye-balls were harvested from BALB/c mice (6-8 weeks of age) for immunofluorescent confocal microscopic studies.

Results. The data demonstrate, for the first time, that in addition to its expression on lymphatic vessels, LYVE-1 was expressed on CD45⁺, CD11b⁺, and CD31^- conjunctival cells, indicating a bone-marrow-derived monocytic lineage. Surprisingly, the number of cells that expressed LYVE-1 decreased during corneal inflammation, in conjunction with ingrowth of lymphatics into the cornea.

Conclusions. A new population of monocytic cells has been found to express LYVE-1 in normal conjunctiva. These cells that normally express LYVE-1 may act as a reservoir for lymphangiogenesis and cell recruitment when the immune system is challenged.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1397798

DOI: 10.1167/iovs.05-0975
PubMed: 16303945
PubMed Central: 1397798

Affiliations:

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<author><name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name>
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<front><div type="abstract" xml:lang="en"><p id="P1"><bold>P<sc>urpose</sc>
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 Lymphatic vessel endothelial hyaluronic acid receptor (LYVE-1) is a newly discovered lymphatic-specific marker. To date, there is no report of its expression on conjunctival cells. The purpose of this study was to investigate the expression of LYVE-1 in normal conjunctiva, to phenotype LYVE-1<sup>+</sup>
 cells, and to study changes in their expression levels during corneal inflammation.</p>
<p id="P2"><bold>M<sc>ethods</sc>
.</bold>
 Flatmounted conjunctivae or cross sections of eye-balls were harvested from BALB/c mice (6-8 weeks of age) for immunofluorescent confocal microscopic studies.</p>
<p id="P3"><bold>R<sc>esults</sc>
.</bold>
 The data demonstrate, for the first time, that in addition to its expression on lymphatic vessels, LYVE-1 was expressed on CD45<sup>+</sup>
, CD11b<sup>+</sup>
, and CD31<sup>-</sup>
 conjunctival cells, indicating a bone-marrow-derived monocytic lineage. Surprisingly, the number of cells that expressed LYVE-1 decreased during <italic>corneal</italic>
 inflammation, in conjunction with ingrowth of lymphatics into the cornea.</p>
<p id="P4"><bold>C<sc>onclusions</sc>
.</bold>
 A new population of monocytic cells has been found to express LYVE-1 in normal conjunctiva. These cells that normally express LYVE-1 may act as a reservoir for lymphangiogenesis and cell recruitment when the immune system is challenged.</p>
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<name sortKey="Cursiefen, Claus" sort="Cursiefen, Claus" uniqKey="Cursiefen C" first="Claus" last="Cursiefen">Claus Cursiefen</name>
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<name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name>
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Novel Expression and Characterization of Lymphatic Vessel Endothelial Hyaluronate Receptor 1 (LYVE-1) by Conjunctival Cells

Novel Expression and Characterization of Lymphatic Vessel Endothelial Hyaluronate Receptor 1 (LYVE-1) by Conjunctival Cells

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